【Tetrahedron 1967,23, 943-955 】
反應(yīng)機(jī)理
反應(yīng)實(shí)例
A solution containing 0.1 g N-(4-methyloxazol-2-yl)-N-(pent-4-enyl)acetamide(0.5 mmol) and 0.06 g DBU (0.4 mmol) in 2 mL toluene in a sealed tube under an argonatmosphere was heated at 180?C for 20 h. Then the solvent was removed under reducedpressure, and the residue was purifified by flflash silica gel chromatography to give 0.3 g1-acetyl-7-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine as a pale yellow oil, in a yield of39%. (Note: It requires 0.842 g starting material to afford 39% naphthyridine derivative ina yield of 39%, but it was stated as 0.1 g in the original article.)
【J. Org. Chem., 1999, 64, 3595.】
A solution of 0.15 g oxazole alcohol (0.41 mmol) and 0.05 g DBN (0.41 mmol) in 60 mLanhydrous o-dichlorobenzene was deoxygenated with argon for 45 min. The mixture washeated at 150?C under an argon atmosphere for 1.5 h and then cooled to room temperature.Upon removal of solvent in vacuo, the residue was purifified by flflash chromatography usingMeOH/EtOAc (1:49) as the eluent to afford 0.10 g pyridine alcohol as a pale yellow oil, ina yield of 71%.
【J. Org. Chem., 1989, 54, 5580】
【J. Org. Chem. 1977, 42, 2039-2040 】
【J. Org. Chem. 1984, 49, 4325-4332 】
【Tetrahedron Lett. 2000，41，10251-10255 】
參考資料
Wang, Zerong (2010). Comprehensive Organic Name Reactions and Reagents || Kondrat'eva Pyridine Synthesis. 1668-1671.
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雜-Diels–Alder反應(yīng)
