堿性條件下利用過硫酸鉀氧化苯胺在鄰位引入酚羥基的反應(yīng)。通常氧化優(yōu)先發(fā)生在氨基的鄰位得到鄰羥基產(chǎn)物。苯酚類底物在相同條件下被氧化的反應(yīng)被稱為Elbs過硫酸鹽氧化反應(yīng)(Elbs persulfate oxidation)。
反應(yīng)機(jī)理
另外一種可能的機(jī)理是：
反應(yīng)實(shí)例
參考文獻(xiàn)
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Sims were at the Royal Cancer Hospital in London, UK.
2. Boyland, E.; Sims, P. J. Chem. Soc. 1954, 980.
3. Behrman, E. J. J. Am. Chem. Soc. 1967, 89, 2424.
4. Krishnamurthi, T. K.; Venkatasubramanian, N. Indian J. Chem., Sect. A 1978, 16A,
28.
5. Behrman, E. J.; Behrman, D. M. J. Org. Chem. 1978, 43, 4551.
6. Srinivasan, C.; Perumal, S.; Arumugam, N. J. Chem. Soc., Perkin Trans. 2 1985, 1855.
7. Behrman, E. J. Org. React. 1988, 35, 421
