一個較實用的合成醛的方法，反應(yīng)一般在室溫下進(jìn)行，反應(yīng)時間較短，可氧化大部分伯醇、烯丙醇和芐醇，而且產(chǎn)率較高，副反應(yīng)較少。一般仲醇很難反應(yīng)，可能會生成亞硝酸酯。
反應(yīng)示例
A typical procedure for oxidation of 4-nitrobenzylalcohol: a mixture of NaNO2(1035 mg, 15mmol) and 4-nitrobenzyl alcohol (5 mmol) in acetic anhydride (2 mmol) was stirred. A spontaneous exothermic reaction took place which was controlled by cooling the mixture in ice. After completion of the reaction (TLC), the product was extracted with ether (2 × 10 ml). Removal of the solvent under reduced pressurea.orded crude 4-nitrobenzaldehyde which was further puri.ed by column chromatography(petroleum ether–ethyl acetate, 9 : 1).
Reference: J. Chem. Soc., Perkin Trans. 1, 2000, 3559–3560
