在鈀催化下通過導向基團（如吡啶和嘧啶）進行C-H位乙酰氧基化得反應.1,6
催化循環(huán)
反應實例
苯醌在反應中起到關鍵的促進作用。
在鈀催化的C-H鍵官能團化得過程中導向基團的作用非常顯著。
參考文獻
1. Dick, A. R.; Hull, K. L.; Sanford, M. S. J. Am. Chem. Soc. 2004, 126, 2300–2301.Melanie S. Sanford was born in New Bedford, MA, in 1975. She received a B.S. and M.S. in chemistry from Yale University in 1996 before obtaining her Ph.D. at California Institute of Technology with Professor Robert Grubbs in 2001. She then completed postdoctoral studies at Princeton University working with Professor John Groves. In 2003, she joined the faculty of the University of Michigan where she is currently the Moses Gomberg Collegiate Professor of Chemistry as well as Arthur F. Thurnau Professor of Chemistry. Her research program focuses on the development of new catalysts and catalytic transformations for applications in the synthesis of useful organic molecules.
2. Kalyani, D.; Deprez, N. R.; Desai, L. V.; Sanford, M. S. J. Am. Chem. Soc. 2005, 127,7330–7331.
3. Kalyani, D.; Sanford, M. S. Org. Lett. 2005, 7, 4149–4152.
4. Hull, K. L.; Lanni, E. L.; Sanford, M. S. J. Am. Chem. Soc. 2006, 128, 14047–14047.(Mechanistic insight).
5. Hull, K. L.; Sanford, M. S. J. Am. Chem. Soc. 2007, 129, 11904–11905.
6. Desai, L. V.; Stowers, K. J.; Sanford, M. S. J. Am. Chem. Soc. 2008, 130, 13285–13293.
7. Stowers, K. J.; Sanford, M. S. Org. Lett. 2009, 11, 4584–4587. (Mechanistic insight).
8. Lyons, T. W.; Sanford, M. S. Chem. Rev. 2010, 110, 1147–1169. (Review).
9. Lyons, T. W.; Hull, K. L.; Sanford M. S. J. Am. Chem. Soc. 2011, 133, 4455–4464.(Regioselectivity).
10. Emmert, M. H.; Cook, A. K.; Xie, Y. J.; Sanford, M. S. Angew. Chem. Int. Ed. 2011,50, 9409–9412.
11. Neufeldt, S. R.; Sanford, M. S. Acc. Chem. Res. 2012, 45, 936–946. (Review).
編譯自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Sanford reaction，page 115-116.
