Baran試劑，二烷基亞磺酸鋅鹽，可以直接對(duì)雜環(huán)芳烴C-H鍵進(jìn)行官能團(tuán)化?，F(xiàn)在很多Baran試劑都可以買到。6,7
反應(yīng)機(jī)理
一種機(jī)理如下，形成CF3自由基參與反應(yīng)。5
另外一種反應(yīng)速率完全不同的機(jī)理也被觀察到，此機(jī)理現(xiàn)在還在研究階段。10
反應(yīng)實(shí)例
咖啡因的二氟甲基化。
Baran試劑對(duì)喹啉的兩個(gè)氫連續(xù)進(jìn)行官能團(tuán)化。
利用Langlois試劑（三氟甲烷亞磺酸鈉）進(jìn)官能團(tuán)化。
參考文獻(xiàn)
1. Tordeux, M.; Langlois, B.; Wakselman, C. J. Chem. Soc., Perkin Trans. 1 1990,2293–2299.
2. Langlois, B. R.; Laurent, E.; Roidot, N. Tetrahedron Lett. 1991, 32, 7525–7528.
3. Clavel, J. L.; Langlois, B.; Laurent, E.; Roidot, N. Phosphorus, Sulfur, and Silicon 1991, 58, 463–466.
4. Kino, T.; Nagase, Y.; Ohtsuka, Y.; Yamamoto, K.; Uraguchi, D.; Tokuhisa, K.;
Yamakawa, T. J. Fluorine Chem. 2010, 131, 98–105.
5. Ji, Y.; Brueckl, T.; Baxter, R. D.; Fujiwara, Y.; Seiple, I. B.; Su, S.; Blackmond, D. G.; Baran, P. S. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 14411–14415. Phil S. Baran is currently a Professor in the Department of Chemistry at The Scripps Research Institute and Member of The Skaggs Institute for Chemical Biology. He was born in New Jersey in 1977, received his B.S. in chemistry from NYU in 1997, his Ph.D. at The Scripps Research Institute in 2001 (NSF fellow with K.C. Nicolaou), and from 2001–2003 he was an NIH postdoctoral fellow at Harvard in the laboratory of E. J. Corey. He has published over 120 scientific articles (H-Factor = 40) and has recently released a book in heterocyclic chemistry. His laboratory is focused on the invention of new reactions of broad utility and synthesizing complex natural products in a scalable, economic fashion. He recently won the John D. and Catharine T. MacArthur award. 【Phil S. Baran現(xiàn)任斯克利普斯研究所教授，斯卡格化學(xué)生物學(xué)研究所成員。他1977年出生于新澤西州，1997年獲得紐約大學(xué)的化學(xué)學(xué)士學(xué)位，2001年在斯克利普斯研究所獲得Ph.D.（在美國全國衛(wèi)生基金會(huì)與 K.C. Nicolaou是同事）。2001年到2003年在哈佛大學(xué)E. J. Corey的實(shí)驗(yàn)室讀美國國立衛(wèi)生研究院博士后。他發(fā)表了超過120篇學(xué)術(shù)論文（H因子=40），最近還出版了一本雜環(huán)化學(xué)方面的書。他的實(shí)驗(yàn)室主要研究方向是開發(fā)新反應(yīng)的更廣的應(yīng)用領(lǐng)域和利用更容易操作的成本低得新方法合成復(fù)雜的天然產(chǎn)物。他最近獲得了John D. and Catharine T. MacArthur獎(jiǎng)?！?/p>
6. Fujiwara, Y.; Dixon, J. A.; Rodriguez, R. A.; Baxter, R. D.; Dixon, D. D.; Collins, M.R.; Blackmond, D. G.; Baran, P. S. J. Am. Chem. Soc. 2012, 134, 1494–1497.
7. Fujiwara, Y.; Dixon, J. A.; O’Hara, F.; Funder, E. D.; Dixon, D. D.; Rodriguez, R. A.; Baxter, R. D.; Herle, B.; Sach, N.; Collins, M. R.; Ishihara, Y.; Baran, P. S. Nature 2012, 492, 95–99.
8. Zhou, Q.; Ruffoni, A.; Gianatassio, R.; Fujiwara, Y.; Sella, E.; Shabat, D.; Baran, P. S. Angew. Chem. Int. Ed. 2013, 52, 3949–3952
9. O’Hara, F.; Baxter, R. D.; O’Brien, A. G.; Collins, M. R.; Dixon, J. A.; Fujiwara, Y.; Ishihara, Y.; Baran, P. S. Nature Protocols 2013, 8, 1042–1047.
10. Baxter, R. D.; Blackmond, D. G. Tetrahedron 2013, 69, 5604–5608.
11. O’Hara, F.; Blackmond, D. G.; Baran, P. S. J. Am. Chem. Soc. 2013, 135, 12122–12134.
編譯自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Baran reagents，page 18-20.
